Shannon Westin
香农·韦斯汀
MD, MPH
Professor and Deputy Chair, Department of Gynecologic Oncology and Reproductive Medicine妇科肿瘤与生殖医学系教授及副系主任
👥Biography 个人简介
Shannon Westin, MD, MPH is a prominent gynecologic oncologist at MD Anderson Cancer Center specializing in ovarian cancer and novel DNA damage response therapeutics. She was a key investigator on the ARIEL4 rucaparib trial and leads early-phase studies combining ATR inhibitors with PARP blockade to overcome resistance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ARIEL4 Trial and Rucaparib in BRCA-Mutated Ovarian Cancer
Served as key investigator on ARIEL4, confirming rucaparib monotherapy as an effective treatment option in BRCA1/2-mutated, heavily pretreated ovarian cancer.
ATR Inhibitor Combinations for PARP Resistance
Pioneered early-phase clinical investigation of ATR inhibitors combined with PARP inhibitors to overcome acquired resistance in recurrent ovarian cancer, expanding the DNA damage response therapeutic landscape.
Representative Works 代表性著作
Rucaparib versus chemotherapy in BRCA1- or BRCA2-mutated, platinum-sensitive ovarian cancer (ARIEL4)
The Lancet Oncology (2022)
Phase III trial confirming rucaparib activity versus standard chemotherapy in BRCA-mutated, platinum-sensitive recurrent ovarian cancer.
A phase I trial of the ATR inhibitor berzosertib in combination with rucaparib in recurrent ovarian cancer
Journal of Clinical Oncology (2023)
First-in-class combination demonstrating tolerability and early efficacy signals for ATR plus PARP inhibition in recurrent ovarian cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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