Sham Mailankody
沙姆·马伦科迪
MBBS
Attending Physician, Myeloma Service & Associate Member骨髓瘤科主治医师暨副研究员
👥Biography 个人简介
Sham Mailankody is a leading MSK investigator in BCMA-targeted therapies for myeloma. He was a key clinical trialist for idecabtagene vicleucel (bb2121), the first approved BCMA CAR-T therapy, and continues to advance next-generation immunotherapy approaches.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Idecabtagene Vicleucel (ide-cel) Development
Served as principal investigator at MSK for the KarMMa trial leading to FDA approval of ide-cel, the first BCMA-directed CAR-T cell therapy in relapsed/refractory myeloma in 2021.
BCMA-Targeted Therapy Landscape
Contributed clinical trial and translational research defining optimal sequencing of BCMA antibody-drug conjugates, bispecifics, and CAR-T therapies to maximize patient outcomes and manage resistance.
Real-World CAR-T Outcomes
Led MSK analyses characterizing real-world safety and efficacy of commercial BCMA CAR-T therapies, identifying predictors of response and toxicity to guide patient selection in clinical practice.
Representative Works 代表性著作
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma (KarMMa)
New England Journal of Medicine (2021)
Pivotal phase II trial demonstrating 73% ORR with ide-cel, establishing BCMA CAR-T as a treatment option in late-line myeloma.
BCMA-Targeted Therapies in Multiple Myeloma: A Review
Clinical Cancer Research (2022)
Comprehensive review comparing antibody-drug conjugates, bispecifics, and CAR-T approaches targeting BCMA in myeloma.
Real-World Outcomes with Commercial Ide-cel in Multiple Myeloma
Blood (2024)
Multi-center real-world analysis of ide-cel outcomes outside clinical trial settings, identifying prognostic factors.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Carl H. June
University of Pennsylvania
Michel Sadelain
Memorial Sloan Kettering Cancer Center
Crystal L. Mackall
Stanford University
Katy Rezvani
MD Anderson Cancer Center
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留下邮箱，当我们发布与 Sham Mailankody（Memorial Sloan Kettering Cancer Center）相关的新研究或访谈时，我们会通知你。
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