Seth Coffelt

Seth Coffelt has demonstrated how tumor-derived G-CSF drives emergency granulopoiesis and neutrophil mobilization that promotes breast cancer metastasis, revealing that cancer cells co-opt the granulopoietic response to generate immunosuppressive neutrophils. His work showed that G-CSF-mobilized neutrophils suppress anti-tumor T cell immunity through gamma-delta T cell-dependent mechanisms. He has identified G-CSF as a potential therapeutic target to interrupt the pro-metastatic neutrophil axis. His research reveals how cancers exploit physiological hematopoietic responses for immune evasion.