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Translational Medicine / 转化医学HIF-1 Discovery, Hypoxia Response

Gregg Semenza

MD, PhD

🏢Johns Hopkins University School of Medicine🌐USA

Professor of Genetic Medicine

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Key Contributions

👥Biography 个人简介

Gregg Semenza discovered hypoxia-inducible factor 1 and defined its role as a master regulator of the cellular response to low oxygen, sharing the 2019 Nobel Prize in Physiology or Medicine. His work connects oxygen sensing to erythropoiesis, angiogenesis, and tumor progression. He continues to investigate HIF-directed therapies for cancer.

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🧪Research Fields 研究领域

HIF-1
hypoxia
erythropoietin
cancer metabolism
Nobel Prize 2019

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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