Scott R. Plotkin
斯科特·普洛特金
MD, PhD
Director, Neurofibromatosis Clinic; Professor of Neurology神经纤维瘤病门诊主任；神经病学教授
👥Biography 个人简介
Dr. Plotkin is the foremost clinical expert on NF2 and schwannomatosis in North America, directing MGH's comprehensive NF clinic. He pioneered the use of bevacizumab for NF2-associated vestibular schwannomas and leads international NF2 clinical trials and the REiNS outcome measure consortium.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Bevacizumab for NF2 Vestibular Schwannoma
Conducted the pivotal trial demonstrating bevacizumab's efficacy in shrinking NF2-associated vestibular schwannomas and improving hearing, establishing anti-VEGF therapy as a treatment option for this previously untreatable condition.
REiNS International Collaboration
Founded and chairs the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) consortium, developing standardized outcome measures and endpoints for NF clinical trials to enable cross-trial comparisons.
Representative Works 代表性著作
Hearing Improvement After Bevacizumab in Neurofibromatosis Type 2
New England Journal of Medicine (2009)
First clinical evidence that bevacizumab reduces vestibular schwannoma volume and improves hearing in NF2 patients, opening an entirely new therapeutic avenue for this devastating syndrome.
Recommendations for the Design of Clinical Trials for Neurofibromatosis
Neurology (2013)
REiNS consortium consensus guidelines for NF clinical trial design, standardizing endpoints and outcome measures that have since been adopted by regulatory agencies and NF research consortia worldwide.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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