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Translational Medicine / 转化医学Colorectal Cancer, BRAF-Mutant CRC

Scott Kopetz

MD, PhD

🏢MD Anderson Cancer Center🌐USA

Professor of Gastrointestinal Medical Oncology

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👥Biography 个人简介

Scott Kopetz at MD Anderson is a world leader in BRAF-mutant colorectal cancer, leading the BEACON-CRC trial that established encorafenib plus cetuximab as standard of care for BRAF V600E CRC. His laboratory work on RAS/RAF signaling in CRC has defined feedback mechanisms that distinguish colon BRAF from melanoma BRAF tumors. He has been instrumental in defining predictive biomarkers for targeted therapy in CRC. His translational research programs have shaped the precision medicine approach to advanced colorectal cancer.

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🧪Research Fields 研究领域

BRAF V600E colorectal cancer
encorafenib cetuximab CRC
BEACON CRC trial
RAS RAF pathway CRC
precision oncology colorectal

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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