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Translational Medicine / 转化医学Lung Cancer, First-Line Immunotherapy

Scott Gettinger

MD

🏢Yale Cancer Center🌐USA

Professor of Medicine; Co-Director, Thoracic Oncology Program

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👥Biography 个人简介

Scott Gettinger has been at the forefront of nivolumab development in lung cancer and contributed to investigations elucidating why PD-L1 selection failed to enhance outcomes in the first-line CheckMate-026 trial. His laboratory research examines T-cell exhaustion, immune resistance mechanisms, and novel combination strategies to overcome immunotherapy resistance in NSCLC. He has co-authored seminal long-term follow-up studies for nivolumab in NSCLC and participates in multi-institution first-line IO clinical trials. Gettinger continues to advance understanding of tumor-immune interactions in thoracic malignancies.

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🧪Research Fields 研究领域

nivolumab NSCLC development
CheckMate-026 PD-L1 selection
squamous cell lung cancer IO
IO resistance mechanisms lung
first-line nivolumab ipilimumab squamous

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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