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Translational Medicine / 转化医学Anti-CTLA-4 plus PD-1 Mechanisms, Lung Cancer

Scott Gettinger

MD

🏢Yale Cancer Center🌐USA

Associate Professor, Medical Oncology

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👥Biography 个人简介

Scott Gettinger is a thoracic oncologist at Yale who has contributed to elucidating the mechanisms of synergy between anti-PD-1 and anti-CTLA-4 agents, including the role of Treg depletion within tumors by CTLA-4 blockade. His translational studies have analyzed the immune contexture of NSCLC tumors in relation to combination immunotherapy response and characterized genomic features associated with response versus resistance. He participated in early CheckMate trials of nivolumab plus ipilimumab in NSCLC and has led Yale-based immunotherapy trials.

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🧪Research Fields 研究领域

nivolumab ipilimumab NSCLC combinational mechanisms
ipilimumab Treg depletion tumor
anti-CTLA-4 mechanism combination synergy
lung cancer combined immunotherapy biomarkers
lung tumor immune contexture

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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