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Translational Medicine / 转化医学Bifunctional Antibody Engineering

Janine Schuurman

PhD

🏢Genmab🌐Netherlands

Chief Scientific Officer

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Key Contributions

👥Biography 个人简介

Janine Schuurman leads the scientific organization at Genmab, where she has been instrumental in developing the DuoBody bispecific antibody platform based on controlled Fab-arm exchange, enabling the efficient generation of bispecific antibodies from two parental IgG1 antibodies. This technology has produced multiple clinical-stage bispecific antibodies including epcoritamab for lymphoma, which received FDA approval. Her work on the HexaBody platform for enhancing complement-dependent cytotoxicity represents another innovative approach to engineering antibody effector function.

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🧪Research Fields 研究领域

DuoBody bispecific technology
Fab-arm exchange
Bispecific antibody manufacturing
HexaBody complement technology
Antibody multimerization

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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