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Translational Medicine / 转化医学IO Breast Cancer Combinations, TNBC

Sara Tolaney

MD, MPH

🏢Dana-Farber Cancer Institute / Harvard Medical School🌐USA

Associate Director, Susan F. Smith Center for Women's Cancers

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👥Biography 个人简介

Sara Tolaney is a breast oncologist who has led clinical investigations into immunotherapy combinations in breast cancer, including pembrolizumab plus chemotherapy in KEYNOTE-522 and studies combining checkpoint inhibitors with ADCs, PARP inhibitors, and CDK4/6 inhibitors. Her research has explored the immunologic basis for combination activity in TNBC and HER2-positive breast cancer, and she has been a primary investigator on multiple trials testing novel IO+targeted therapy combinations. She co-chairs the ASCO Cancer Research Committee and serves on multiple guideline panels.

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🧪Research Fields 研究领域

pembrolizumab atezolizumab TNBC combination
IO+ADC breast cancer combinations
CDK4/6 IO breast cancer synergy
TNBC immunotherapy combinations clinical trials
HER2 IO combination breast cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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