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Translational Medicine / 转化医学Cancer Biomarker & Pathology

Sanjay Mukhopadhyay

桑杰·穆霍帕德亚伊

MD

🏢Cleveland Clinic(克利夫兰诊所)🌐USA

Section Head, Pulmonary Pathology肺部病理学科主任

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h-index
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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Leading pulmonary pathologist specializing in molecular profiling of lung tumors. Established clinical protocols for ALK and ROS1 immunohistochemistry in NSCLC, improving turnaround time for actionable molecular diagnosis and guiding targeted therapy selection.

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🧪Research Fields 研究领域

Lung Cancer Molecular Pathology肺癌分子病理学
ALK/ROS1 IHCALK/ROS1免疫组化
Pulmonary Biomarker Diagnostics肺部生物标志物诊断

🎓Key Contributions 主要贡献

ALK/ROS1 IHC Implementation

Pioneered clinical validation of ALK and ROS1 IHC as cost-effective screening tools before confirmatory FISH, significantly reducing diagnostic time for patients eligible for targeted therapy.

Lung Adenocarcinoma Classification

Contributed to refining the IASLC/ATS/ERS classification of lung adenocarcinoma, clarifying histologic subtypes with prognostic significance and implications for surgical resection margins.

Representative Works 代表性著作

[1]

Immunohistochemical Detection of ALK in Non-Small Cell Lung Carcinoma: Comparison with FISH

American Journal of Surgical Pathology (2023)

Validated D5F3 clone IHC as a reliable screening method for ALK rearrangement with high sensitivity and specificity in NSCLC.

[2]

ROS1 IHC as a Screening Tool for ROS1 Fusion in Lung Adenocarcinoma

Journal of Thoracic Oncology (2022)

Established performance characteristics of D4D6 clone for ROS1 screening in a large clinical cohort.

🏆Awards & Recognition 奖项与荣誉

🏆United States and Canadian Academy of Pathology Outstanding Investigator Award
🏆Cleveland Clinic Innovator Award
🏆American Thoracic Society Recognition Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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