Sangeeta N. Bhatia

Sangeeta Bhatia is the John J. and Dorothy Wilson Professor at MIT and a Howard Hughes Medical Institute Investigator. She holds MD and PhD degrees from Harvard and MIT respectively, giving her a unique bridge between clinical medicine and engineering. Her laboratory develops nanotechnology-based diagnostic tools that could revolutionize cancer early detection. She invented "synthetic biomarkers" — protease-activated nanoparticles that detect tumor-associated enzymes and release reporter fragments into urine, enabling non-invasive, inexpensive cancer diagnostics potentially as a simple urinalysis. She is also a pioneer of liver microsystems (liver-on-chip), developing micropatterned co-culture systems that maintain functional hepatocytes for drug metabolism testing and disease modeling. Her work bridges cancer nanomedicine, diagnostics, and liver biology with direct clinical translation.

Sangeeta Bhatia 是麻省理工学院约翰·威尔逊教授，也是霍华德·休斯医学研究所研究员。她分别在哈佛大学和MIT获得医学和博士学位，在临床医学和工程学之间架起了独特的桥梁。 她的实验室开发了基于纳米技术的诊断工具，可能彻底革新癌症早期检测。她发明了"合成生物标志物"——蛋白酶激活的纳米颗粒，能够检测肿瘤相关酶并将报告片段释放到尿液中，从而实现非侵入性、低成本的癌症诊断，可能像简单的尿液分析一样容易。