Sandra D'Angelo
桑德拉·丹杰洛
MD
Associate Attending Physician, Sarcoma Medical Oncology; Associate Member, Human Oncology and Pathogenesis Program肉瘤内科肿瘤学副主任医师；人类肿瘤学与发病机制项目副成员
👥Biography 个人简介
Sandra D'Angelo, MD is an Associate Attending at MSK specializing in immunotherapy for soft tissue sarcomas. She leads clinical development of NY-ESO-1-targeted T-cell therapies and cancer-testis antigen-based approaches in synovial sarcoma and myxoid liposarcoma. Her research bridges STS tumor immunology with first-in-human cell therapy and checkpoint inhibitor trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
NY-ESO-1 T-Cell Therapy in Synovial Sarcoma
Led pivotal trials of NY-ESO-1 TCR-engineered T-cell therapy (letetresgene autoleucel/GSK3377794) in synovial sarcoma, demonstrating durable objective responses in this chemotherapy-resistant sarcoma subtype.
STS Immune Microenvironment
Characterized the immune landscape of major STS subtypes and identified immunologically 'hot' histotypes amenable to checkpoint blockade, providing the mechanistic rationale for subtype-specific immunotherapy trial design.
Representative Works 代表性著作
Efficacy of Adoptive Cell Therapy with NY-ESO-1 Specific T Cells in Synovial Sarcoma
Journal of Clinical Oncology (2018)
Reported objective responses to NY-ESO-1 TCR T-cell therapy in synovial sarcoma patients, demonstrating proof-of-concept for cancer-testis antigen-directed cell therapy in STS.
Pembrolizumab in Combination with Axitinib in Unresectable or Metastatic Soft Tissue Sarcomas
Nature Medicine (2022)
Demonstrated meaningful activity of pembrolizumab plus axitinib in alveolar soft part sarcoma and other STS subtypes, informing combination immunotherapy strategies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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