Sancy A. Leachman
桑西·利奇曼
MD, PhD
Professor and Chair of Dermatology; Director, Melanoma and Skin Cancer Program皮肤科教授兼主席；黑色素瘤与皮肤癌项目主任
👥Biography 个人简介
Sancy Leachman is Professor and Chair of Dermatology at Oregon Health and Science University and Director of the Melanoma and Skin Cancer Program. Her translational research spans UV-induced DNA damage and mutational signatures in skin carcinogenesis, hereditary predisposition syndromes for NMSC, and the development of AI-enhanced dermoscopy tools for early skin cancer detection. She leads the NCI-funded Cancer Moonshot initiative focused on preventive dermatology and is an ASCO and AAD national thought leader.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
UV Mutational Signatures in NMSC
Characterised UV-induced C>T mutational signatures at dipyrimidine sites in basal cell and squamous cell carcinoma genomes, providing mechanistic evidence linking solar UV exposure to specific driver mutations in PTCH1, TP53, and NOTCH pathway genes.
AI-Assisted Early Detection
Developed and validated deep learning algorithms for dermoscopic image analysis of basal cell carcinoma and CSCC, demonstrating performance approaching expert dermatologist sensitivity and specificity in prospective clinical validation studies.
Representative Works 代表性著作
Mutational landscape of cutaneous squamous cell carcinoma and UV signature dominance in early versus advanced disease
Nature Communications (2022)
Whole-exome sequencing of primary and metastatic CSCC samples identifying UV-signature mutations in NOTCH1/2, FAT1, and CDKN2A as key drivers and potential immunotherapy biomarkers.
Deep learning dermoscopy for non-melanoma skin cancer detection: multicentre prospective validation
Journal of the American Academy of Dermatology (2024)
Prospective multi-site validation of a convolutional neural network achieving 91% sensitivity for BCC and 87% for CSCC diagnosis from dermoscopic images.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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