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Translational Medicine / 转化医学Nanomedicine & Drug Delivery

Samuel I. Stupp

塞缪尔·斯塔普

PhD

🏢Northwestern University(西北大学)🌐USA

Board of Trustees Professor; Director, Simpson Querrey Institute董事会信托教授;辛普森·奎里研究所所长

110
h-index
2
Key Papers
6
Awards
3
Key Contributions

👥Biography 个人简介

Samuel Stupp is the Board of Trustees Professor of Materials Science, Chemistry, Medicine, and Biomedical Engineering at Northwestern University, and Director of the Simpson Querrey Institute for BioNanotechnology. Stupp is a world leader in self-assembling biomaterials, particularly peptide amphiphiles (PAs) — molecules that spontaneously organize into nanofibers mimicking the extracellular matrix. His PA nanostructures have demonstrated remarkable ability to promote spinal cord regeneration, cardiac repair, and cancer drug delivery. His group showed that engineered PA nanofibers displaying instructive signals can guide tissue regeneration in mouse models of complete spinal cord injury, enabling paralyzed mice to walk again — one of the most dramatic demonstrations of regenerative nanomedicine. His laboratory bridges chemistry, materials science, and clinical medicine.

Samuel Stupp 是西北大学材料科学、化学、医学和生物医学工程的董事会信托教授,也是辛普森·奎里生物纳米技术研究所所长。 Stupp 是自组装生物材料领域的世界领军人物,尤其是肽两亲分子(PA)——自发组织成模拟细胞外基质的纳米纤维的分子。他的PA纳米结构显示出促进脊髓再生、心脏修复和癌症药物递送的显著能力。

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🧪Research Fields 研究领域

Peptide Amphiphile Nanostructures肽两亲分子纳米结构
Self-Assembling Biomaterials自组装生物材料
Cancer Drug Delivery Hydrogels癌症药物递送水凝胶
Regenerative Nanomedicine再生纳米医学
Supramolecular Chemistry超分子化学

🎓Key Contributions 主要贡献

Peptide Amphiphile Nanofibers for Regeneration

Developed PA nanofibers that self-assemble into bioactive scaffolds displaying molecular signals guiding tissue regeneration. Showed remarkable spinal cord regeneration in mouse paralysis models.

Cancer Immunotherapy Hydrogels

Engineered self-assembling hydrogel platforms for local cancer immunotherapy delivery, combining checkpoint inhibitors and stimulatory signals in tumor-localized depots that avoid systemic toxicity.

Supramolecular Biomaterial Design

Pioneer of using supramolecular chemistry principles to design biomaterials with emergent biological properties. Established design rules linking molecular architecture to nanofiber properties and cellular responses.

Representative Works 代表性著作

[1]

Bioactivity of Peptide Amphiphile Nanofibers

Science (2001)

First demonstration that PA nanofibers displaying bioactive IKVAV sequence can promote neurite growth, founding the field of peptide biomaterials for regenerative medicine.

[2]

Angiogenesis in ischemic tissue by supramolecular systems encapsulating VEGF

PNAS (2006)

Demonstrated that PA nanostructures can deliver VEGF to promote angiogenesis in ischemic heart and limb models.

🏆Awards & Recognition 奖项与荣誉

🏆National Academy of Sciences Member
🏆National Academy of Engineering Member
🏆American Academy of Arts and Sciences Fellow
🏆MRS Von Hippel Award
🏆ACS Polymer Chemistry Award
🏆Inaugural Kabiller Prize in Nanoscience and Nanomedicine

📄Data Sources 数据来源

Last updated: 2026-04-05 | All information from publicly available academic sources

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