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Translational Medicine / 转化医学Antibiotic Impact on IO, Microbiome Depletion

Samuel Klein

MD

🏢Vanderbilt University Medical Center🌐USA

Medical Oncologist, Microbiome Research

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Key Papers
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Key Contributions

👥Biography 个人简介

Samuel Klein investigates the clinical impact of antibiotic use on cancer immunotherapy outcomes, having contributed to multiple retrospective and prospective analyses showing that broad-spectrum antibiotic exposure prior to or during checkpoint inhibitor therapy is associated with worse overall survival and reduced response rates. His work has prompted clinical recommendations for antibiotic stewardship in patients receiving immunotherapy.

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🧪Research Fields 研究领域

antibiotics immunotherapy outcomes
gut microbiome depletion IO
antibiotic prior IO
microbiome-IO clinical outcomes
lung cancer microbiome IO

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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