Ryan Sullivan
瑞安·沙利文
MD
Associate Professor of Medicine, Co-Director of Melanoma Program医学副教授，黑色素瘤项目联合主任
👥Biography 个人简介
Ryan Sullivan is a melanoma oncologist at Massachusetts General Hospital specializing in BRAF/MEK inhibitor combinations and overcoming drug resistance. His translational research bridges laboratory discoveries on resistance mechanisms to innovative clinical trial designs for advanced melanoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRAF/MEK Inhibitor Drug Resistance
Elucidated reactivation of the MAPK pathway and alternative resistance mechanisms to BRAF/MEK inhibitors in melanoma, guiding development of triplet therapy and intermittent dosing strategies.
Triplet Targeted-Immunotherapy Combinations
Pioneered clinical trials combining BRAF/MEK inhibitors with PD-1 checkpoint blockade, investigating sequencing strategies to maximize antitumor immunity and delay resistance.
Translational Biomarker Research
Developed and validated circulating tumor DNA and immunohistochemical biomarkers for predicting and monitoring response to targeted therapy and immunotherapy in melanoma patients.
Representative Works 代表性著作
Intermittent BRAF Inhibition in BRAF V600E Melanoma: A Phase 2 Trial
Nature Medicine (2019)
Demonstrated that intermittent dosing of BRAF inhibitors can delay acquired resistance and extend benefit.
Atezolizumab plus Vemurafenib and Cobimetinib in BRAF-Mutated Melanoma (IMspire150)
The Lancet (2020)
Phase III trial of triple combination immunotherapy plus targeted therapy showing improved PFS.
Mechanisms of Resistance to BRAF Inhibitors in Melanoma
Journal of Clinical Oncology (2015)
Comprehensive review defining clinical and genomic mechanisms underpinning targeted therapy resistance in melanoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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