Paolo Antonio Ascierto
保罗·安东尼奥·阿西尔托
MD
Director, Melanoma, Cancer Immunotherapy and Innovative Therapy Unit黑色素瘤、癌症免疫治疗与创新治疗部主任
👥Biography 个人简介
Paolo Ascierto is a leading Italian melanoma oncologist who has driven global trials of ipilimumab and nivolumab combinations. His research on dual checkpoint blockade and BRAF/MEK targeted therapy has profoundly shaped melanoma treatment algorithms worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Dual Checkpoint Blockade
Led CheckMate 067 trial demonstrating superior outcomes of ipilimumab plus nivolumab over monotherapy, establishing combination immunotherapy as a key option in advanced melanoma.
BRAF/MEK Inhibitor Combinations
Advanced clinical evaluation of dabrafenib-trametinib and encorafenib-binimetinib combinations, improving progression-free survival in BRAF V600-mutant metastatic melanoma.
Adjuvant Melanoma Therapy
Contributed to adjuvant nivolumab trials in resected stage III/IV melanoma, establishing new standards for preventing recurrence after surgery.
Representative Works 代表性著作
Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma (CheckMate 067)
New England Journal of Medicine (2015)
Pivotal trial demonstrating superior PFS and OS with nivolumab-ipilimumab combination over ipilimumab monotherapy.
Combined Nivolumab and Ipilimumab versus Ipilimumab Alone in Patients with Advanced Melanoma
New England Journal of Medicine (2019)
Long-term 5-year outcomes from CheckMate 067 confirming durable survival benefit of dual checkpoint blockade.
Binimetinib versus Dacarbazine in Patients with Advanced NRAS-Mutant Melanoma (NEMO)
The Lancet Oncology (2017)
First trial demonstrating clinical benefit of MEK inhibition in NRAS-mutant melanoma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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