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Translational Medicine / 转化医学HER2 Genomics, Amplification

Ruth Bhatt

PhD

🏢Vanderbilt University🌐USA

Research Associate Professor

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👥Biography 个人简介

Ruth Bhatt studies the genomic landscape of HER2 amplification and co-amplification events that influence HER2-targeted therapy outcomes. Her research characterized how co-amplified genes including MYC and CDK12 cooperate with HER2 to drive aggressive phenotypes. She has also examined intratumoral heterogeneity of HER2 amplification and its implications for biopsy-based subtyping. Her genomic insights help explain differential responses to trastuzumab and T-DXd across HER2+ breast cancers.

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🧪Research Fields 研究领域

HER2 amplification mechanisms
ERBB2 co-amplification
HER2 intratumor heterogeneity
single cell HER2
copy number variation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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