Russell Jones

Russell Jones studies the metabolism of immune cells with focus on how metabolic states govern T cell differentiation, function, and anti-tumor immunity. His laboratory has revealed how tumor-mediated metabolic competition impairs immune cell function and how reprogramming immune cell metabolism can enhance anti-tumor responses. He discovered key roles for mTOR signaling and mitochondrial metabolism in T cell differentiation and memory formation. His work connects metabolic biology with immunotherapy, identifying metabolic interventions that could enhance CAR-T or checkpoint inhibitor efficacy.