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Translational Medicine / 转化医学Myelofibrosis, Ruxolitinib, Quality of Life

Ruben Mesa

MD

🏢Mays Cancer Center / UT Health San Antonio🌐USA

Executive Director

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👥Biography 个人简介

Ruben Mesa has contributed to myelofibrosis clinical research, including contributions to COMFORT-I and COMFORT-II trials establishing ruxolitinib as the first approved therapy for myelofibrosis — demonstrating both reduction in splenomegaly and improved constitutional symptoms and survival. His work on patient-reported outcomes in MPN and on second-generation JAK inhibitors for ruxolitinib-intolerant or resistant myelofibrosis addresses important clinical needs.

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🧪Research Fields 研究领域

myelofibrosis ruxolitinib treatment
COMFORT I II ruxolitinib
pacritinib fedratinib myelofibrosis
MPN patient-reported outcomes
myelofibrosis splenomegaly treatment

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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