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Translational Medicine / 转化医学Clinical Trials

Roy S. Herbst

M.D., Ph.D.

🏢Yale Cancer Center🌐USA

Chief of Medical Oncology; Associate Director for Translational Research

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Key Papers
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Key Contributions

👥Biography 个人简介

Roy Herbst is a leader in thoracic oncology and immunotherapy clinical development. He has led practice-changing clinical trials in lung cancer, including pivotal studies of EGFR inhibitors and checkpoint immunotherapy combinations. Herbst is particularly known for his work on biomarker-driven treatment selection and has contributed to multiple FDA approvals in lung cancer.

Roy Herbst是胸部肿瘤学和免疫治疗临床开发的领导者。他领导了肺癌领域改变实践的临床试验,包括EGFR抑制剂和检查点免疫治疗组合的关键研究。Herbst以其在生物标志物驱动的治疗选择方面的工作而闻名,并为肺癌领域的多个FDA批准做出了贡献。

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🧪Research Fields 研究领域

Lung Cancer肺癌
Immunotherapy免疫治疗
Clinical Trials临床试验

🎓Key Contributions 主要贡献

Lung Cancer Immunotherapy

Led pivotal pembrolizumab trials in NSCLC establishing checkpoint blockade in lung cancer.

Biomarker Development

Advanced PD-L1 as predictive biomarker for immunotherapy selection.

Representative Works 代表性著作

[1]

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010)

Lancet (2016)

Pivotal trial establishing pembrolizumab in NSCLC.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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