D. Ross Camidge
罗斯·卡米奇
MB BChir, PhD, FRCP, FACP
Joyce Zeff Chair in Lung Cancer Research; Director, Thoracic Oncology Clinical and Clinical Translational Research Programs乔伊斯·泽夫肺癌研究主席；胸部肿瘤临床及转化研究项目主任
👥Biography 个人简介
One of the most prolific thoracic oncology clinical researchers globally. Led the PROFILE crizotinib trials revolutionizing ALK-positive NSCLC treatment, contributed major data on lorlatinib and EGFR resistance mechanisms, and pioneered understanding of CNS involvement in TKI-treated NSCLC.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PROFILE Crizotinib Trials
Principal investigator for PROFILE 1014, demonstrating crizotinib superiority over chemotherapy in ALK-positive NSCLC, establishing ALK as the second major oncogenic driver after EGFR in NSCLC.
EGFR Resistance and Next-Generation TKIs
Published landmark studies on mechanisms of acquired resistance to EGFR TKIs and strategies using third-generation inhibitors and combination approaches to overcome resistance in advanced NSCLC.
Representative Works 代表性著作
Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer (PROFILE 1014)
New England Journal of Medicine (2014)
Definitive phase III trial establishing crizotinib as standard of care for previously untreated ALK-positive NSCLC.
Lorlatinib in Non–Small-Cell Lung Cancer with ALK or ROS1 Rearrangement: An International, Multicenter, Open-Label, Single-Arm, Phase 1/2 Trial
Lancet Oncology (2018)
Pivotal study establishing lorlatinib activity across multiple ALK resistance mutations, supporting approval of next-generation ALK TKI.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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