Rona Yaeger
罗娜·耶格
MD
Associate Attending Physician, Gastrointestinal Oncology Service消化道肿瘤科副主治医师
👥Biography 个人简介
Rona Yaeger is MSK's leading investigator in HER2-amplified and BRAF-mutant colorectal cancer. She led the MOUNTAINEER trial establishing tucatinib plus trastuzumab for HER2-amplified CRC and has defined the molecular landscape of BRAF non-V600E alterations, shaping 2026 precision CRC therapy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HER2-Amplified CRC MOUNTAINEER Trial
Led MOUNTAINEER trial demonstrating tucatinib plus trastuzumab achieved durable responses in HER2-amplified CRC, resulting in FDA approval and a new treatment class for CRC.
BRAF Non-V600E CRC Biology
Characterized the diverse landscape of non-V600E BRAF mutations in CRC, identifying class 1, 2, and 3 BRAF alterations with distinct therapeutic implications.
Representative Works 代表性著作
Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER)
Cancer Discovery (2023)
Pivotal MOUNTAINEER trial demonstrating tucatinib plus trastuzumab efficacy leading to FDA approval in HER2-amplified CRC.
Genomic alterations observed in colitis-associated cancers are distinct from those found in sporadic colorectal cancers
Cancer Research (2019)
Characterized molecular landscape distinctions in colitis-associated versus sporadic CRC with therapeutic implications.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Naiyer A. Rizvi
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