Roisin Connolly
罗辛·康纳利
MB BCh BAO, MD
Associate Professor of Oncology; Director, Breast Cancer Research Program肿瘤学副教授；乳腺癌研究项目主任
👥Biography 个人简介
Roisin Connolly, MB BCh MD is an associate professor at Johns Hopkins investigating HER2-targeted therapies and immunotherapy combinations in endometrial cancer, with expertise in epigenetic priming strategies to enhance immune checkpoint blockade efficacy.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
HER2-Targeted Therapy in Endometrial Cancer
Investigated HER2 amplification as a therapeutic target in serous endometrial cancer and led early-phase trials evaluating anti-HER2 agents in gynecologic malignancies.
Epigenetic Priming for Immunotherapy Enhancement
Pioneered epigenetic priming approaches using HDAC and DNMT inhibitors to sensitize endometrial and other cancers to immune checkpoint blockade, increasing immunotherapy response rates.
Representative Works 代表性著作
HER2 amplification in uterine serous carcinoma and response to trastuzumab-based therapy
Gynecologic Oncology (2020)
Characterized HER2 amplification frequency in uterine serous carcinoma and assessed clinical activity of trastuzumab-containing regimens.
Epigenetic priming with vorinostat and azacitidine sensitizes endometrial cancer to pembrolizumab
Clinical Cancer Research (2022)
Phase I/II trial demonstrating epigenetic priming significantly enhanced pembrolizumab activity in endometrial cancer with durable responses.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
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