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Translational Medicine / 转化医学Arginine Auxotrophy in Cancer

Mark Rohandel

PhD

🏢Roswell Park Comprehensive Cancer Center🌐USA

Associate Professor of Cancer Metabolism

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Key Contributions

👥Biography 个人简介

Mark Rohandel investigates arginine auxotrophy in tumors that have lost argininosuccinate synthetase 1 and their vulnerability to arginine depleting agents. His translational work supports clinical trials of pegylated arginine deiminase in sarcoma and hepatocellular carcinoma. He continues to define metabolic determinants of response.

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🧪Research Fields 研究领域

arginine metabolism
ASS1
arginine deiminase
cancer metabolism
amino acid deprivation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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