Roger Reddel
MD, PhD
Director, Children's Medical Research Institute
👥Biography 个人简介
Roger Reddel defined the Alternative Lengthening of Telomeres (ALT) pathway as a telomerase-independent mechanism of telomere maintenance in cancer. His work identified ALT-associated PML bodies (APBs), C-circles as ALT biomarkers, and the critical role of ATRX/DAXX mutations in activating ALT. His research has been foundational in developing therapeutic strategies specifically targeting ALT-positive cancers including gliomas and sarcomas.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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