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Translational Medicine / 转化医学BRAF Resistance, Melanoma

Roger Lo

MD

🏢UCLA Jonsson Comprehensive Cancer Center🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Roger Lo at UCLA is a leading expert in resistance to BRAF/MEK inhibitors in melanoma. His research has characterized adaptive and acquired resistance mechanisms including BRAF amplification, alternative splicing, and transcriptional plasticity enabling phenotype switching. His work has established the molecular basis for combination therapy approaches to delay resistance and improve outcomes in BRAF-mutant melanoma.

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🧪Research Fields 研究领域

BRAF resistance
melanoma drug resistance
RAF pathway
adaptive resistance
transcriptional plasticity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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