Roger Greenberg
PhD
Professor, Department of Cancer Biology; Director, Penn Center for Genome Integrity
👥Biography 个人简介
Roger Greenberg is a cell biologist who discovered key regulatory mechanisms of chromatin modification at DNA double-strand breaks, including the RNF8/RNF168 ubiquitin-signaling cascade that controls BRCA1 and 53BP1 recruitment to damage sites. His work elucidated how the balance between BRCA1 and 53BP1 dictates the choice between homologous recombination and end-joining repair pathways. His discoveries have direct implications for understanding PARP inhibitor sensitivity and the role of BRCA1 in chromatin-level regulation of genome integrity.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-03-01 | All information from publicly available academic sources
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