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Translational Medicine / 转化医学Neuroendocrine Tumors

Rocío García-Carbonero

罗西奥·加西亚-卡博内罗

MD, PhD

🏢Hospital Universitario 12 de Octubre, Complutense University of Madrid(马德里12十月大学医院,马德里康普顿斯大学)🌐Spain

Head, Gastrointestinal and Endocrine Tumors Unit; Professor of Oncology胃肠与内分泌肿瘤部门主任,肿瘤学教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Rocío García-Carbonero, MD, PhD is Head of the Gastrointestinal and Endocrine Tumors Unit at Hospital Universitario 12 de Octubre and Professor of Oncology at Complutense University of Madrid, where she leads one of Spain's premier NET and neuroendocrine carcinoma (NEC) clinical and research programs. She is internationally recognized for her expertise in high-grade NETs and NECs — a heterogeneous group of aggressive tumors for which therapeutic options remain limited — and has led investigational studies and evidence syntheses that have shaped ENETS and ESMO guideline recommendations for these challenging cancers. Dr. García-Carbonero has chaired the ENETS NEC working group and authored consensus guidelines for diagnosis and treatment of poorly differentiated neuroendocrine carcinomas, which represent the most authoritative international recommendations for this subgroup. Her research has characterized the molecular biology, Ki-67 thresholds, and platinum sensitivity of high-grade GEP-NETs and NECs, contributing to the WHO 2019 classification framework. She has also led prospective studies of temozolomide and alkylating agent combinations in well-differentiated G3 NETs, a particularly undercharacterized population. A recipient of several national and international awards for oncology research, Dr. García-Carbonero serves on the ESMO Faculty for GI and NET cancers, is a past Scientific Committee Chair for ENETS, and has published over 180 peer-reviewed articles spanning basic, translational, and clinical NET research.

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🧪Research Fields 研究领域

High-Grade NETs and NEC
Platinum-Based Chemotherapy in NEC
Temozolomide-Based Regimens
Large Cell Neuroendocrine Carcinoma
ENETS Guideline Development
Biomarker Research in NETs

🎓Key Contributions 主要贡献

High-Grade NET and NEC Classification and Treatment Guidelines

Chaired the ENETS working group on poorly differentiated neuroendocrine carcinomas and authored landmark consensus papers establishing diagnostic criteria, Ki-67 threshold distinctions, platinum sensitivity predictors, and treatment algorithms for NEC — providing the most comprehensive evidence-based guidance for this understudied population.

WHO 2019 NET Classification: Translating G3 NET Biology into Taxonomy

Contributed pivotal clinical and translational evidence supporting the WHO 2019 reclassification that separated well-differentiated G3 NETs from poorly differentiated NECs, demonstrating distinct molecular profiles, platinum sensitivity patterns, and clinical outcomes that justified this clinically impactful taxonomic revision.

Alkylating Agent Therapy in Well-Differentiated G3 NETs

Led prospective investigations of temozolomide-based regimens specifically in well-differentiated G3 NETs — a population previously conflated with NEC — demonstrating meaningful activity distinct from platinum chemotherapy and generating data that informed treatment algorithms for this newly recognized NET subtype.

Representative Works 代表性著作

[1]

ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Poorly Differentiated Carcinomas

Neuroendocrinology (2012)

Comprehensive ENETS consensus guidelines for NEC management, covering pathological diagnosis, staging, platinum-based chemotherapy use, and second-line strategies — the field-defining reference for this aggressive subtype.

[2]

High-Grade Gastroenteropancreatic Neuroendocrine Carcinomas

Journal of Clinical Oncology (2016)

Large retrospective cohort characterizing outcomes and platinum sensitivity across GEP-NEC subtypes, providing evidence that RB1 loss and p53 expression predict cisplatin response in this population.

[3]

Poorly Differentiated Neuroendocrine Carcinomas: Are We Making Progress?

Annals of Oncology (2019)

Comprehensive state-of-the-art review addressing advances in NEC molecular characterization, second-line therapy options, and immunotherapy prospects — widely cited as the modern reference for NEC management strategy.

🏆Awards & Recognition 奖项与荣誉

🏆SEOM (Spanish Society of Medical Oncology) Research Award
🏆ENETS Scientific Committee Chair (past)
🏆ESMO Faculty — Gastrointestinal Cancers
🏆Fundación BBVA Health Sciences Prize

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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