Robert A. Weinberg
罗伯特·温伯格
PhD
Daniel K. Ludwig Professor for Cancer Research; Founding Member, Whitehead Institute丹尼尔·K·路德维希癌症研究教授；怀特黑德研究所创始成员
👥Biography 个人简介
Robert Weinberg is a co-discoverer of the first human oncogene (RAS) and the first tumor suppressor gene cloned (RB1), and co-authored the landmark Cancer Hallmarks framework with Douglas Hanahan. He has defined the molecular basis of oncogenesis, tumor suppression, and EMT-driven cancer invasion and metastasis over five decades.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
First Human Oncogene Isolation (RAS)
Isolated and characterized the first transforming oncogene from a human bladder carcinoma cell line as a mutated version of the normal HRAS proto-oncogene, defining oncogene activation by point mutation.
RB1 Cloning — First Tumor Suppressor Gene
Cloned RB1, the retinoblastoma susceptibility gene, as the first tumor suppressor gene, establishing the two-hit hypothesis molecularly and defining a new class of cancer genes controlling cell cycle entry.
Epithelial-Mesenchymal Transition (EMT) in Metastasis
Demonstrated that EMT programs enable carcinoma cells to acquire invasive and stem-cell properties, and that mesenchymal-epithelial transition (MET) facilitates metastatic colonization, providing a mechanistic basis for metastasis.
Representative Works 代表性著作
A transforming gene in two human bladder carcinomas
Nature (1982)
Identified HRAS as a mutant transforming gene in human bladder cancer, the first direct isolation of an activated oncogene from a human tumor.
The Hallmarks of Cancer
Cell (2000)
Co-authored with Hanahan the foundational framework defining six hallmark capabilities acquired during human tumor development; the most-cited cancer biology review in history.
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
Science (2008)
Demonstrated that EMT confers breast cancer cells with CD44+/CD24- stem cell properties, linking EMT to cancer stem cell biology and therapeutic resistance.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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