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Translational Medicine / 转化医学Cold-to-Hot Tumors, Anti-CD40 Agonists

Robert Vonderheide

MD, DPhil

🏢University of Pennsylvania🌐USA

Director, Abramson Cancer Center

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Key Contributions

👥Biography 个人简介

Robert Vonderheide pioneered anti-CD40 agonist antibody trials in pancreatic cancer, demonstrating that CD40 agonism can reprogram myeloid cells and prime T cell responses. His work established CD40 agonism as a leading strategy to convert immune-cold pancreatic tumors into immune-hot lesions. He leads the Penn cancer immunotherapy program.

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🧪Research Fields 研究领域

anti-CD40 agonist
pancreatic cancer immunotherapy
T cell priming
tumor immunology
cold tumor conversion

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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