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Translational Medicine / 转化医学TAP Transporters, Peptide Translocation

Robert Tampe

PhD

🏢Goethe University Frankfurt🌐Germany

Professor of Biochemistry, Director of Institute of Biochemistry

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Key Contributions

👥Biography 个人简介

Robert Tampe has resolved the structure and mechanism of the TAP transporter complex that translocates proteasome-generated peptides into the endoplasmic reticulum for MHC-I loading. His structural studies revealed how viral immune evasion proteins block TAP function, providing insights into analogous mechanisms exploited by cancer cells. He has established the molecular basis for how TAP deficiency leads to immune evasion in cancer.

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🧪Research Fields 研究领域

TAP transporter
peptide translocation ER
ABC transporter immunology
viral TAP inhibition
antigen processing machinery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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