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Translational Medicine / 转化医学Metronomic Chemotherapy, Angiogenesis

Robert Kerbel

MD

🏢Sunnybrook Research Institute🌐Canada

Senior Scientist

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👥Biography 个人简介

Robert Kerbel at Sunnybrook is a leading cancer research scientist who developed the concept of metronomic chemotherapy — frequent low-dose chemotherapy designed to have anti-angiogenic activity by continuously targeting dividing endothelial cells while avoiding the toxicities of maximum tolerated dose regimens. He has conducted extensive preclinical studies of bevacizumab combinations and contributed to understanding anti-angiogenic drug resistance.

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🧪Research Fields 研究领域

metronomic chemotherapy
anti-angiogenic chemotherapy
drug resistance anti-angiogenic
bevacizumab combinations
preclinical tumor models

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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