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Translational Medicine / 转化医学Adaptive Therapy, Evolutionary Game Theory

Robert Gatenby

MD

🏢Moffitt Cancer Center🌐USA

Distinguished Professor and Chair of Radiology

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Key Contributions

👥Biography 个人简介

Robert Gatenby pioneered the application of evolutionary and ecological principles to cancer therapy, developing the adaptive therapy paradigm that uses treatment holidays to maintain drug-sensitive populations and prevent competitive release of resistant clones. His mathematical models of the Warburg effect provided the first quantitative explanation for aerobic glycolysis in cancer. Adaptive therapy trials in prostate cancer have demonstrated significant clinical benefit.

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🧪Research Fields 研究领域

adaptive therapy
evolutionary game theory cancer
Warburg effect mathematics
competitive release
cancer ecology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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