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Translational Medicine / 转化医学Oncolytic Virus, Herpes Oncolytic Engineering

Robert Coffin

PhD

🏢Replimune Ltd.🌐UK

Chief Scientific Officer

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Key Contributions

👥Biography 个人简介

Robert Coffin is the inventor of T-VEC and a pioneer in engineering herpes simplex virus-based oncolytic therapies. He designed the molecular architecture of T-VEC including deletion of ICP34.5 and ICP47 genes and insertion of GM-CSF to amplify local immune responses. He founded Replimune to develop next-generation armed oncolytic viruses, including RP2 and RP3, that deliver additional immunostimulatory payloads.

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🧪Research Fields 研究领域

herpes simplex virus oncolytic engineering
T-VEC engineering design
RP2 RP3 oncolytic platform
armed oncolytic virus immunostimulation
oncolytic virus GM-CSF delivery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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