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Translational Medicine / 转化医学Senolytic Therapy Clinical Research

Paul Robbins

PhD

🏢University of Minnesota🌐USA

Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of Institute on the Biology of Aging and Metabolism

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👥Biography 个人简介

Paul Robbins co-developed the high-throughput senolytic drug screening platform that identified fisetin and other natural product senolytics, and co-leads clinical trials evaluating their efficacy in reducing age-related disease burden including cancer. His research on NF-kB signaling in senescent cells has revealed druggable targets for SASP suppression as an alternative to senolysis. He combines basic science discovery with clinical translation in the senolytic therapy field.

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🧪Research Fields 研究领域

Senolytic drug screening
Fisetin clinical trials
NF-kB in senescence
Anti-inflammatory senolytics
Senescent cell heterogeneity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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