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Translational Medicine / 转化医学Bifunctional Antibody Engineering

Naiyer Rizvi

MD

🏢Columbia University Irving Medical Center🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Naiyer Rizvi is a leading clinical investigator of bifunctional antibody therapeutics in lung cancer and other solid tumors at Columbia University, conducting pivotal trials of bispecific antibodies that simultaneously block PD-1 and CTLA-4 or engage T cells with tumor antigens. His clinical research has demonstrated the potential of bispecific checkpoint-blocking antibodies to improve response rates compared to mono-specific checkpoint inhibitors. He has contributed to defining the optimal clinical development strategies for bifunctional antibodies in solid tumor indications.

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🧪Research Fields 研究领域

Bispecific antibody clinical trials
Immune checkpoint bispecifics
Lung cancer immunotherapy
PD-1/CTLA-4 bispecific development
Combination immunotherapy strategies

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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