Rinath Jeselsohn
里纳斯·杰塞尔索恩
MD
Associate Professor of Medicine; Breast Oncologist医学副教授；乳腺肿瘤科医生
👥Biography 个人简介
Expert in estrogen receptor biology and endocrine resistance at Dana-Farber. Pioneer in characterizing ESR1 mutations as drivers of CDK4/6 inhibitor resistance and developing elacestrant and next-generation SERD strategies for ER+ metastatic breast cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ESR1 Mutations and Endocrine Resistance
Characterized acquired ESR1 mutations as a major mechanism of resistance to aromatase inhibitors and CDK4/6 inhibitors, providing the scientific basis for elacestrant's approval in ESR1-mutant ER+ metastatic breast cancer.
Representative Works 代表性著作
ESR1 Mutations—A Mechanism for Acquired Endocrine Resistance in Breast Cancer
Clinical Cancer Research (2023)
Seminal work delineating ESR1 mutation landscape, frequency, and clinical implications for treatment sequencing in ER+ metastatic breast cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
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