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Translational Medicine / 转化医学Super-enhancer Condensates, Transcription

Richard Young

PhD

🏢Massachusetts Institute of Technology🌐USA

Professor of Biology, Member of Whitehead Institute

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👥Biography 个人简介

Richard Young has made landmark contributions to understanding how super-enhancers drive gene expression through the formation of phase-separated condensates containing Mediator, RNA Pol II, and transcription factors. His work revealed that oncogenic transcription factors hijack condensate biology to activate cancer gene programs. These insights have opened new therapeutic avenues for disrupting aberrant transcriptional condensates in cancer.

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🧪Research Fields 研究领域

super-enhancer condensates
transcriptional regulation
phase separation transcription
gene regulation
cancer epigenetics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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