Richard Simon
理查德·西蒙
DSc
Chief Emeritus, Computational & Systems Biology Branch, NCI; Professor, Georgetown UniversityNCI计算与系统生物学部荣誉主任；乔治城大学教授
👥Biography 个人简介
Richard Simon, DSc is a foundational figure in biomarker-driven clinical trial design at the NCI. His statistical frameworks, including enrichment designs, adaptive signature designs, and master protocols, have become the methodological bedrock for precision oncology trials and companion diagnostic development worldwide.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Biomarker Enrichment Strategies for Clinical Trials
Developed foundational statistical frameworks for biomarker enrichment strategies in clinical trials, including the all-comers, enrichment, and marker-stratified designs used across precision oncology globally.
Adaptive Signature Design and Master Protocols
Invented the adaptive signature design and contributed extensively to master protocol methodology, enabling biomarker discovery and validation within single efficient trial frameworks.
Representative Works 代表性著作
Using Genomics in Clinical Trial Design
Clinical Cancer Research (2008)
Landmark methodological paper establishing principles for incorporating genomic biomarkers into clinical trial design, widely cited across precision oncology.
Biomarker-Based Clinical Trial Designs for Precision Medicine
Nature Reviews Drug Discovery (2017)
Comprehensive review of biomarker trial design strategies including enrichment, adaptive signature, and master protocol approaches for precision oncology.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
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MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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