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Translational Medicine / 转化医学APC, Wnt Signaling, CRC

Rene Bhatt

PhD

🏢Leiden University Medical Center🌐Netherlands

Molecular Oncologist

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Key Contributions

👥Biography 个人简介

Rene Bhatt studies APC tumor suppressor function and Wnt-beta-catenin signaling in colorectal cancer. APC mutation is the initiating event in approximately 80% of sporadic CRC and causes familial adenomatous polyposis (FAP). Understanding how APC loss activates beta-catenin transcription to initiate colorectal tumorigenesis, and how to therapeutically target the Wnt pathway downstream, remains an active area of research.

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🧪Research Fields 研究领域

APC tumor suppressor
Wnt beta-catenin APC CRC
APC colorectal cancer
familial adenomatous polyposis
Wnt pathway cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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