Reinhard Büttner
莱因哈德·比特纳
MD, PhD
Professor and Director, Institute of Pathology病理学研究所教授兼主任
👥Biography 个人简介
Leading European lung cancer pathologist and molecular diagnostics innovator. Spearheaded PD-L1 standardization initiatives in Germany and contributed extensively to ESMO biomarker testing guidelines for NSCLC, enabling precision immunotherapy and targeted therapy selection.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PD-L1 Testing Standardization Germany
Led the German network for PD-L1 IHC harmonization across certified lung cancer centers, establishing quality assurance frameworks that reduced inter-laboratory variability and improved clinical decision reliability.
Liquid Biopsy Validation in Lung Cancer
Validated ctDNA-based detection of EGFR T790M and KRAS G12C mutations as alternatives to re-biopsy at progression, integrating liquid biopsy into routine lung cancer molecular pathology workflows in Germany.
Representative Works 代表性著作
Harmonization of PD-L1 Testing in Non-Small Cell Lung Cancer: Results of a German Multicenter Study
Journal of Thoracic Oncology (2023)
Multi-center German study demonstrating improved concordance in PD-L1 scoring after harmonization training using reference slide sets.
Liquid Biopsy for EGFR and KRAS Mutation Detection at Disease Progression in NSCLC
Lung Cancer (2022)
Prospective validation of plasma ctDNA sensitivity and specificity versus tissue re-biopsy for resistance mutation detection in 420 NSCLC patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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