Rebecca Kristeleit
丽贝卡·克里斯特莱特
MBBS, PhD, FRCP
Professor of Gynaecological Cancer Medicine; Honorary Consultant Medical Oncologist妇科肿瘤医学教授；荣誉顾问肿瘤内科医生
👥Biography 个人简介
Rebecca Kristeleit is a Professor of Gynaecological Cancer Medicine at UCL Cancer Institute and a leading UK expert in PARP inhibitor development for ovarian cancer. She has been a key investigator in the ARIEL2 and ARIEL3 trials of rucaparib, which defined HRD biomarkers and established rucaparib as maintenance therapy in platinum-sensitive recurrent ovarian cancer, contributing to its regulatory approval in Europe and the USA.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ARIEL2 and ARIEL3: Rucaparib in Recurrent Ovarian Cancer
Key investigator in ARIEL2 phase II and ARIEL3 phase III trials demonstrating rucaparib maintenance therapy improved PFS in platinum-sensitive recurrent ovarian cancer, with ARIEL2 defining genomic LOH as a predictive HRD biomarker.
Biomarker-Driven PARP Inhibitor Selection
Advanced translational research linking BRCA mutation status and genomic scarring scores to rucaparib treatment outcomes, enabling precision patient selection strategies for PARP inhibitor therapy in recurrent ovarian cancer.
Representative Works 代表性著作
Rucaparib Maintenance Treatment for Recurrent Ovarian Carcinoma after Response to Platinum Therapy (ARIEL3)
The Lancet (2017)
Phase III trial establishing rucaparib maintenance significantly improved PFS vs placebo in recurrent platinum-sensitive ovarian cancer across HRD biomarker subgroups.
ARIEL2 Part 1: Identification of Low-Grade Serous Ovarian Carcinoma Responsive to Rucaparib
Journal of Clinical Oncology (2017)
Defined genomic LOH as a predictive biomarker for rucaparib response and stratified ovarian cancer patients beyond BRCA mutation status.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 丽贝卡·克里斯特莱特 的研究动态
Follow Rebecca Kristeleit's research updates
留下邮箱，当我们发布与 Rebecca Kristeleit（University College London Cancer Institute / Guy's and St Thomas' NHS Foundation Trust）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment