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Translational Medicine / 转化医学HIF Prolyl Hydroxylation, Oxygen Sensing

Peter Ratcliffe

MD

🏢Francis Crick Institute / University of Oxford🌐UK

Director of Clinical Research

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Key Papers
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Key Contributions

👥Biography 个人简介

Peter Ratcliffe shared the 2019 Nobel Prize in Physiology or Medicine for elucidating oxygen-dependent prolyl hydroxylation of HIF-alpha subunits. His work established the molecular basis of cellular oxygen sensing and catalyzed drug discovery for HIF-targeted therapies. He continues to advance hypoxia biology at the Crick Institute.

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🧪Research Fields 研究领域

HIF
prolyl hydroxylase
oxygen sensing
VHL
Nobel Prize 2019

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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