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Translational Medicine / 转化医学Waldenstrom's Macroglobulinemia, Bortezomib

Ramzi Kotb

MD

🏢University of Ottawa / The Ottawa Hospital Cancer Centre🌐Canada

Associate Professor, Division of Hematology

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Key Papers
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Key Contributions

👥Biography 个人简介

Ramzi Kotb has contributed to clinical research on bortezomib-based regimens for Waldenstrom's macroglobulinemia, including the BDR (bortezomib, dexamethasone, rituximab) approach, and studied proteasome inhibitor activity in WM cells. His work examines how MYD88 and CXCR4 mutation status influences bortezomib response and the rational incorporation of proteasome inhibitors into combination regimens for WM.

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🧪Research Fields 研究领域

bortezomib WM
proteasome inhibitor WM
WM NF-kB pathway
BDR regimen
WM frontline combinations

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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