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Translational Medicine / 转化医学Endometrial Cancer Molecular Subtypes, Carboplatin-Paclitaxel Immunotherapy

Ramez Eskander

MD

🏢UC San Diego Health / Moores Cancer Center🌐USA

Professor, Division of Gynecologic Oncology

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Key Contributions

👥Biography 个人简介

Ramez Eskander is a clinical investigator who has led key studies defining how molecular subclassification of endometrial cancer should inform treatment selection. He participated in the RUBY trial evaluating dostarlimab plus carboplatin-paclitaxel and the GOG3031/ENGOT-en9 trial with pembrolizumab, helping establish immunotherapy plus chemotherapy as first-line standard for advanced endometrial cancer. His research focuses on biomarker-driven therapy selection and the differential benefit of immunotherapy across POLE-ultramutated, MMR-deficient, and p53-mutant endometrial cancer populations.

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🧪Research Fields 研究领域

RUBY pembrolizumab endometrial
molecular subclassification endometrial outcomes
dostarlimab endometrial cancer
GOG3031 carboplatin paclitaxel pembrolizumab
POLE MMR-d endometrial treatment

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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