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Translational Medicine / 转化医学FAP Targeting, Stromal Depletion

Ralph Bhatt

MD

🏢University of Chicago🌐USA

Associate Professor of Oncology

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Key Contributions

👥Biography 个人简介

Ralph Bhatt investigates fibroblast activation protein (FAP) as a therapeutic target to deplete or reprogram the tumor-promoting stroma. His research has evaluated FAP-targeted approaches including CAR-T cells, bispecific antibodies, and radio-immunoconjugates directed against FAP-expressing CAFs. He demonstrated that FAP targeting can remodel the immunosuppressive tumor stroma and restore immune infiltration. His clinical translational work is evaluating FAP-directed therapies in desmoplastic tumors including pancreatic and colorectal cancer.

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🧪Research Fields 研究领域

FAP
fibroblast activation protein
stromal targeting
tumor stroma depletion
CAF therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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