Raffit Hassan
拉菲特·哈桑
MD
Senior Investigator, Thoracic and GI Malignancies Branch胸部与消化道恶性肿瘤科高级研究员
👥Biography 个人简介
Raffit Hassan at the NCI is the world's leading authority on mesothelin-targeted cancer therapy. He discovered mesothelin as a tumor antigen and developed SS1P immunotoxin, amatuximab, and CAR-T approaches against mesothelin-expressing malignancies including mesothelioma, lung adenocarcinoma, and pancreatic cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Mesothelin Biology
Characterized mesothelin as a cell surface glycoprotein overexpressed in mesothelioma and several solid tumors, establishing it as a major therapeutic target.
Immunotoxin Development
Developed SS1P (anti-mesothelin immunotoxin) and conducted first-in-human trials, demonstrating antitumor activity and paving the way for next-generation mesothelin-directed agents.
CAR-T Therapy
Pioneered mesothelin-directed CAR-T cell therapy clinical trials in solid tumors including mesothelioma, achieving early clinical responses and advancing the solid tumor CAR-T field.
Representative Works 代表性著作
Mesothelin-targeted immunotherapy of ovarian cancer and malignant mesothelioma
Current Opinion in Oncology (2010)
Comprehensive review of mesothelin biology and therapeutic targeting, establishing the scientific foundation for multiple clinical programs.
Amatuximab and pemetrexed/cisplatin in pleural mesothelioma (COMMAND trial)
Annals of Oncology (2014)
First phase II trial of anti-mesothelin antibody combined with chemotherapy, demonstrating feasibility and signals of efficacy.
Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus IV infusion
Clinical Cancer Research (2007)
Established the safety profile and early efficacy signals of mesothelin immunotoxin, enabling later combination strategies.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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