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Translational Medicine / 转化医学Brain Metastasis, Leptomeningeal Disease

Priscilla Brastianos

MD

🏢Massachusetts General Hospital🌐USA

Associate Professor of Medicine

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👥Biography 个人简介

Dr. Priscilla Brastianos is a neuro-oncologist at MGH with expertise in the genomic landscape of brain metastases and leptomeningeal disease. She performed seminal genomic analyses revealing clinically actionable mutations unique to brain metastases not present in primary tumors, including PIK3CA and CDK4/6 alterations. Her research also advances intrathecal and CNS-penetrant targeted therapy approaches for leptomeningeal carcinomatosis.

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🧪Research Fields 研究领域

leptomeningeal disease
intrathecal therapy
genomics brain metastases
EGFR CNS penetration
targeted therapy leptomeningeal

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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